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Identification of inhibitors targeting the energy-coupling factor (ECF) transporters
Publikation
Diamanti E,
Souza P,
Setyawati I,
Bousis S,
Monjas L,
Swier L,
Shams A,
Tsarenko A,
Stanek W,
Jäger M,
Marrink S,
slotboom d,
Hirsch A
(2024)
Communications Biology, 7, 1, 10.1038/s42003-024-05770-0, 38195913
Communications Biology, 7, 1, 10.1038/s42003-024-05770-0, 38195913
IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding
Publikation
Hamid R,
Walsh D,
Diamanti E,
Aguilar D,
Lacour A,
Hamed M,
Hirsch A
(2024)
Structure (London, England : 1993), 32, 12, 2390-2398, 10.1016/j.str.2024.10.009, 39510075
Structure (London, England : 1993), 32, 12, 2390-2398, 10.1016/j.str.2024.10.009, 39510075
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum
Publikation
Johannsen S,
Gierse R,
Krüger A,
Edwards R,
Nanna V,
Fontana A,
Di Zhu,
Masini T,
Carvalho L,
Poizat M,
Kieftenbelt B,
Hodge D,
Alvarez S,
Bunt D,
Lacour A,
Shams A,
Meissner K,
Souza E,
Dröge M,
van Vliet B,
Hartog J,
Hutter M,
Held J,
Odom John A,
Wrenger C,
Hirsch* A
(2024)
ACS Infect. Dis., 10.1021/acsinfecdis.3c00670, 38367280
ACS Infect. Dis., 10.1021/acsinfecdis.3c00670, 38367280
Targeting the Plasmodium falciparum IspE Enzyme
Publikation
Diamanti E,
Steinbach A,
Carvalho L,
Ropponen H,
Lacour A,
Hamid R,
Eisa S,
Bravo P,
Bousis S,
Illarionov B,
Fischer M,
Hamed M,
Bach N,
Rottmann M,
Held J,
Witschel M,
Sieber S,
Hirsch A
(2024)
ACS omega, 9, 44, 44465-44473, 10.1021/acsomega.4c06038, 39524657
ACS omega, 9, 44, 44465-44473, 10.1021/acsomega.4c06038, 39524657
Behavioral and electrophysiological responses of the male medfly, Ceratitis capitata, to thymol and carvacrol ethers
Publikation
Tabanca N,
Cloonan K,
Nesterkina M,
Gill M,
Montgomery W,
Kravchenko I,
Kendra P
(2024)
Pest management science, 10.1002/ps.8324, 39096116
Pest management science, 10.1002/ps.8324, 39096116
Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes
Publikation
Chan A,
Ho T,
Fathoni I,
Hamid R,
Hirsch A,
Saliba K,
Leeper F
(2024)
RSC Med. Chem., 15, 5, 1773-1781, 10.1039/D4MD00083H, 38784473
RSC Med. Chem., 15, 5, 1773-1781, 10.1039/D4MD00083H, 38784473
Studying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry
Publikation
Bizzarri L,
Steinbrunn D,
Quennesson T,
Lacour A,
Bianchino G,
Bravo P,
Chaignon P,
Lohse J,
Mäser P,
Seemann M,
van Calenbergh S,
Hirsch A,
Hahne H
(2024)
ACS Infect. Dis., 10, 12, 4087-4102, 10.1021/acsinfecdis.4c00417, 39566904
ACS Infect. Dis., 10, 12, 4087-4102, 10.1021/acsinfecdis.4c00417, 39566904
Synthesis and Structure of a Coordination Polymer of Ni(II) with 2-(4-Bromophenoxy)acetohydrazide
Publikation
Martsynko ?,
Nesterkina M,
Finik ?,
Tsymbaliuk K,
Dyakonenko V,
Shishkina S,
Kravchenko I
(2024)
Molbank, 2024, 2, 10.3390/M1819
Molbank, 2024, 2, 10.3390/M1819
Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy-coupling factor transporters (ECFTs)
Publikation
Haupenthal J,
Rafehi M,
Kany A,
Lespine A,
Stefan K,
Hirsch* A,
Stefan* S
(2024)
Arch. Pharm., 10.1002/ardp.202400267, 38896404
Arch. Pharm., 10.1002/ardp.202400267, 38896404
Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign
Publikation
Johannsen S,
Gierse R,
Olshanova A,
Smerznak E,
Laggner C,
Eschweiler L,
Adeli Z,
Hamid R,
Alhayek A,
Reiling N,
Haupenthal J,
Hirsch A
(2023)
ChemMedChem, 10.1002/cmdc.202200590, 36896721
ChemMedChem, 10.1002/cmdc.202200590, 36896721