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Design and synthesis of thiamine analogues to study their binding to the ECF transporter for thiamine in bacteria
Publikation
Monjas L,
Swier L,
Voogd A,
Oudshoorn R,
Hirsch A,
Slotboom D
(2016)
Med. Chem. Commun., 7, 5, 966-971, 10.1039/C6MD00022C
Med. Chem. Commun., 7, 5, 966-971, 10.1039/C6MD00022C
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism
Publikation
Chen F,
Elgaher W,
Winterhoff M,
Büssow K,
Waqas F,
Graner E,
Pires-Afonso Y,
Casares Perez L,
La Vega L,
Sahini N,
Czichon L,
Zobl W,
Zillinger T,
Shehata M,
Pleschka S,
Bähre H,
Falk C,
Michelucci A,
Schuchardt S,
Blankenfeldt W,
Hirsch A,
Pessler F
(2022)
Nature metabolism, 4, 5, 534-546, 10.1038/s42255-022-00577-x, 35655026
Nature metabolism, 4, 5, 534-546, 10.1038/s42255-022-00577-x, 35655026
Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents
Publikation
Kaya C,
Hirsch A
(2022)
Chimia, 76, 5, 10.2533/chimia.2022.402
Chimia, 76, 5, 10.2533/chimia.2022.402
Screening of Natural Products and Small Molecules Uncovers Novel Coronavirus 1a/1b Frameshifting Inhibitors with Antiviral Properties
Publikation
Kibe A,
Elgaher W,
Rand U,
Zimmer M,
Kany A,
Hermann J,
Müller R,
Cicin-Sain L,
Hirsch A,
Caliskan N
(2022)
SSRN Journal, 10.2139/ssrn.4157446
SSRN Journal, 10.2139/ssrn.4157446
Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages
Publikation
Sake S,
Kosch C,
Blockus S,
Haid S,
Gunesch A,
Zhang X,
Friesland M,
Trummer S,
Grethe C,
Kühnel A,
Rückert J,
Duprex W,
Huang J,
Rameix-Welti M,
Empting M,
Fischer N,
Hirsch A,
Schulz T,
Pietschmann T
(2022)
Antimicrobial agents and chemotherapy, 10.1128/aac.01032-22, 36346232
Antimicrobial agents and chemotherapy, 10.1128/aac.01032-22, 36346232
Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry
Publikation
Bagnolini G,
Balboni B,
Schipani F,
Gioia D,
Veronesi M,
Franco F,
Kaya C,
Jumde R,
Ortega J,
Girotto S,
Hirsch A,
Roberti M,
Cavalli A
(2022)
ACS Med. Chem. Lett., 13, 8, 1262-1269, 10.1021/acsmedchemlett.2c00063, 35978685
ACS Med. Chem. Lett., 13, 8, 1262-1269, 10.1021/acsmedchemlett.2c00063, 35978685
Rheological Properties of Hyaluronic Acid Diluted Solutions as Components of Cosmetics
Publikation
Svetlana Saitarly,
Yuriy Pushkarev,
Nesterkina M,
Serhat Öztürk,
Iryna Kravchenko
(2021)
Biointerface Res Appl Chem, 12, 2, 1907-1915, 10.33263/BRIAC122.19071915
Biointerface Res Appl Chem, 12, 2, 1907-1915, 10.33263/BRIAC122.19071915
Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties
Publikation
Gierse R,
Reddem E,
Alhayek A,
Baitinger D,
Hamid Z,
Jakobi H,
Laber B,
Lange G,
Hirsch A,
Groves
(2021)
Biochemical and Biophysical Research Communications, 539, 10.1016/j.bbrc.2020.12.069, 33421767
Biochemical and Biophysical Research Communications, 539, 10.1016/j.bbrc.2020.12.069, 33421767
Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors
Publikation
Kaya C,
Walter I,
Yahiaoui S,
Sikandar A,
Alhayek A,
Konstantinovic J,
Kany A,
Haupenthal J,
Köhnke J,
Hartmann R,
Hirsch A
(2021)
Angewandte Chemie (International ed. in English), 10.1002/anie.202112295, 34762767
Angewandte Chemie (International ed. in English), 10.1002/anie.202112295, 34762767
Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design
Publikation
Axer A,
Jumde R,
Adam S,
Faust A,
Schäfers M,
Fobker M,
Koehnke J,
Hirsch A,
Gilmour R
(2021)
Chem. Sci., 12, 4, 1286-1294, 10.1039/D0SC04297H
Chem. Sci., 12, 4, 1286-1294, 10.1039/D0SC04297H