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Dr. Asfandyar Sikandar

Über

Asfandyar Sikandar erhielt seinen B.Sc. (Hons) in Biomolecular Science von der University of St. Andrews, UK. Es folgte ein M.Sc. in Biochemie an der University of Calgary, Kanada. Derzeit promoviert er bei Jun. Prof. Jesko Köhnke. Seine Arbeit befasst sich mit der strukturellen und biochemischen Charakterisierung von Proteinen, die an der Naturstoffsynthese und bakteriellen Abwehrmechanismen beteiligt sind.


2021

Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors

Kaya C, Walter I, Yahiaoui S, Sikandar A, Alhayek A, Konstantinovic J, Kany A, Haupenthal J, Köhnke J, Hartmann R, Hirsch A (2021)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202112295

2020

The bottromycin epimerase BotH defines a group of atypical α/β-hydrolase-fold enzymes

Sikandar A, Franz L, Adam S, Santos-Aberturas J, Horbal L, Luzhetskyy A, Truman A, Kalinina O, Koehnke J (2020)

Nat Chem Biol 16 (9): 1013-1018DOI: 10.1038/s41589-020-0569-y

2019

The role of protein-protein interactions in the biosynthesis of ribosomally synthesized and post-translationally modified peptides

Sikandar A, Koehnke J (2019)

Nat. Prod. Rep. 36 (11): 1576-1588DOI: 10.1039/C8NP00064F

2018

Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor

Kany A, Sikandar A, Yahiaoui S, Haupenthal J, Walter I, Empting M, Köhnke J, Hartmann R (2018)

ACS chemical biology 13 (9): 2449-2455DOI: 10.1021/acschembio.8b00257

Adaptation of a Bacterial Multidrug Resistance System Revealed by the Structure and Function of AlbA

Sikandar A, Cirnski K, Testolin G, Volz C, Brönstrup M, Kalinina O, Müller R, Koehnke J (2018)

J. Am. Chem. Soc. 140 (48): 16641-16649DOI: 10.1021/jacs.8b08895

2017

Photorhabdus luminescens lectin A (PllA): A new probe for detecting α-galactoside-terminating glycoconjugates

Beshr G, Sikandar A, Jemiller E, Klymiuk N, Hauck D, Wagner S, Wolf E, Koehnke J, Titz A (2017)

J Biol Chem 292 (48): 19935-19951DOI: 10.1074/jbc.M117.812792

Thioholgamides: Thioamide-Containing Cytotoxic RiPP Natural Products

Kjaerulff L, Sikandar A, Zaburannyi N, Adam S, Herrmann J, Koehnke J, Müller R (2017)

ACS Chem. Biol. 12 (11): 2837-2841DOI: 10.1021/acschembio.7b00676

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

Fu C, Sikandar A, Donner J, Zaburannyi N, Herrmann J, Reck M, Wagner-Döbler I, Koehnke J, Müller R (2017)

Nat Commun 8 (1)DOI: 10.1038/s41467-017-01671-5